40 Hz Blue LED Relieves the Gamma Oscillations Changes Caused by Traumatic Brain Injury in Rat

Xiaoyu Yang; Xuepei Li; Yikai Yuan; Tong Sun; Jingguo Yang; Bo Deng; Hang Yu; Anliang Gao; Junwen Guan

doi:10.3389/fneur.2022.882991

40 Hz Blue LED Relieves the Gamma Oscillations Changes Caused by Traumatic Brain Injury in Rat

Front Neurol. 2022 Jun 21:13:882991. doi: 10.3389/fneur.2022.882991. eCollection 2022.

Authors

Xiaoyu Yang¹, Xuepei Li², Yikai Yuan¹, Tong Sun¹, Jingguo Yang¹, Bo Deng³, Hang Yu³, Anliang Gao⁴, Junwen Guan¹

Affiliations

¹ Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
² Medical Simulation Center, Chengdu First People's Hospital, Chengdu, China.
³ College of Electronic Engineering (College of Meteorological Observation), Chengdu University of Information Technology, Chengdu, China.
⁴ Department of Neurosurgery, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, China.

Abstract

Background: Photobiomodulation (PBM) using low-level light-emitting diodes (LEDs) can be rapidly applied to various neurological disorders safely and non-invasively.

Materials and methods: Forty-eight rats were involved in this study. The traumatic brain injury (TBI) model of rat was set up by a controlled cortical impact (CCI) injury. An 8-channel cortex electrode EEG was fixed to two hemispheres, and gamma oscillations were extracted according to each electrode. A 40 hz blue LED stimulation was set at four points of the frontal and parietal regions for 60 s each, six times per day for 1 week. Modified Neurologic Severity Scores (mNSS) were used to evaluate the level of neurological function.

Results: In the right-side TBI model, the gamma oscillation decreased in electrodes Fp2, T4, C4, and O2; but significantly increased after 1 week of 40 hz Blue LED intervention. In the left-side TBI model, the gamma oscillation decreased in electrodes Fp1, T3, C3, and O1; and similarly increased after 1 week of 40 hz Blue LED intervention. Both left and right side TBI rats performed significantly better in mNSS after 40 hz Blue LED intervention.

Conclusion: TBI causes the decrease of gamma oscillations on the injured side of the brain of rats. The 40 hz Blue LED therapy could relieve the gamma oscillation changes caused by TBI and improve the prognosis of TBI.

Keywords: LED; electroencephalogram; gamma oscillations; rat; traumatic brain injury.