Single-Dose Vaccination Among Infants and Toddlers Provides Modest Protection Against Influenza Illness, Which Wanes After 5 Months

J Infect Dis. 2022 Dec 28;227(1):87-91. doi: 10.1093/infdis/jiac288.

Abstract

In their first season of vaccination, young children are recommended 2 doses of influenza vaccine, but a 2-dose schedule might be difficult to implement in many countries. Within a cohort study of 742 children aged 6 to <24 months in Managua, Nicaragua, this study estimated effectiveness of partial vaccination from 3 to 9 months postvaccination. Vaccine effectiveness was 74% (95% confidence interval [CI], 24%-91%) within 3 months and 55% (95% CI, 10%-77%) within 4 months. There was not significant protection beyond 5 months. Partial vaccination might confer some benefits but should be followed by a second dose.

Keywords: child; cohort study; developing country; influenza vaccine; influenza virus.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Research Support, N.I.H., Extramural

MeSH terms

  • Child, Preschool
  • Cohort Studies
  • Humans
  • Infant
  • Influenza Vaccines*
  • Influenza, Human* / prevention & control
  • Seasons
  • Vaccination

Substances

  • Influenza Vaccines