Locked in a pro-inflammatory state

Elife. 2022 Jul 7:11:e80699. doi: 10.7554/eLife.80699.

Abstract

Macrophages absorbing cells infected with viable SARS-CoV-2 particles fail to transition into an anti-inflammatory state, potentially contributing to a damaging immune reaction linked to severe forms of COVID-19.

Keywords: COVID-19; SARS-CoV-2; efferocytosis; human; hyperinflammation; immunology; inflammation; macrophage polarization; tissue repair.

Publication types

  • Editorial

MeSH terms

  • COVID-19*
  • Humans
  • Inflammation
  • Macrophages
  • SARS-CoV-2*