Electrochemically Enabled Cascade Cyclization Reaction of Aromatic Aldehydes and Pyrazol-5-amines: Synthesis of Bis-pyrazolo[3,4- b:4',3'- e]pyridines

Peng Qian; Shan Jiang; Hua Fan; Siqi Jiang; Longlong Xu; Jiaojiao Liu

doi:10.1021/acs.joc.2c00988

Electrochemically Enabled Cascade Cyclization Reaction of Aromatic Aldehydes and Pyrazol-5-amines: Synthesis of Bis-pyrazolo[3,4- b:4',3'- e]pyridines

J Org Chem. 2022 Jul 15;87(14):9242-9249. doi: 10.1021/acs.joc.2c00988. Epub 2022 Jul 7.

Authors

Peng Qian¹, Shan Jiang², Hua Fan¹, Siqi Jiang¹, Longlong Xu¹, Jiaojiao Liu¹

Affiliations

¹ School of Chemistry and Material Engineering, Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational Institutions, Fuyang Normal University, Fuyang, Anhui 236037, P.R. China.
² Experimental and Training Management Center, Fuyang Normal University, Fuyang, Anhui 236037, P.R. China.

PMID: 35795996
DOI: 10.1021/acs.joc.2c00988

Abstract

A facile method for the synthesis of bis-pyrazolo[3,4-b:4',3'-e]pyridines from easily available aromatic aldehydes and pyrazol-5-amines was developed via electrochemistry. The reaction proceeded smoothly under metal and external chemical oxidant-free conditions, giving a variety of bis-pyrazolo[3,4-b:4',3'-e]pyridines in moderate yields.