A new role for ammonia in tumorigenesis?

Hyun Min Lee; Anushka Nayak; Jiyeon Kim

doi:10.1016/j.cmet.2022.06.009

A new role for ammonia in tumorigenesis?

Cell Metab. 2022 Jul 5;34(7):944-946. doi: 10.1016/j.cmet.2022.06.009.

Authors

Hyun Min Lee¹, Anushka Nayak², Jiyeon Kim³

Affiliations

¹ Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
² Department of Biology, School of Arts and Science, Emory University, Atlanta, GA, USA.
³ Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: jiyeonk@uic.edu.

PMID: 35793658
DOI: 10.1016/j.cmet.2022.06.009

Abstract

Tumor-supporting roles of ammonia have gained greater appreciation in recent years and normally focus on ammonia's role as a nitrogen source. Recently in Nature Metabolism,Cheng et al. (2022) demonstrate a novel, non-nitrogen, metabolism-related role of ammonia as a key activator for lipogenesis by facilitating SREBP-1 activation.

MeSH terms

Ammonia* / metabolism
Carcinogenesis*
Cell Transformation, Neoplastic
Humans
Lipogenesis
Nitrogen / metabolism

Substances

Ammonia
Nitrogen