A neuroimmunometabolic view on the cephalic phase of insulin release

Gitalee Sarker; Ana I Domingos

doi:10.1016/j.cmet.2022.06.005

A neuroimmunometabolic view on the cephalic phase of insulin release

Cell Metab. 2022 Jul 5;34(7):940-942. doi: 10.1016/j.cmet.2022.06.005.

Authors

Gitalee Sarker¹, Ana I Domingos²

Affiliations

¹ Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
² Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. Electronic address: ana.domingos@dpag.ox.ac.uk.

PMID: 35793656
DOI: 10.1016/j.cmet.2022.06.005

Abstract

The cephalic phase of insulin secretion (CPIS) plays a crucial role in glucose homeostasis. However, the neural basis of CPIS and its overall relevance to metabolic health are poorly understood. Here, we preview the findings of Wiedemann et al. (2022) that address the role of IL-1β in the integration of neuro-mediated insulin release following cephalic stimulation and CPIS dysregulation in obesity.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Insulin Secretion
Insulin*
Obesity*

Substances

Insulin

Grants and funding

208576/Z/17/Z/WT_/Wellcome Trust/United Kingdom