Significant Contribution of Interleukin-18 Genotypes to Lung Cancer Risk in Taiwanese

Meng-Feng Wu; Li-Hsiou Chen; Ning-Yi Hsia; Yi-Cheng Shen; Te-Chun Shen; Zhi-Hong Wang; Ya-Chen Yang; Yun-Chi Wang; Wen-Shin Chang; Te-Chun Hsia; DA-Tian Bau; Chia-Wen Tsai

doi:10.21873/anticanres.15825

Significant Contribution of Interleukin-18 Genotypes to Lung Cancer Risk in Taiwanese

Anticancer Res. 2022 Jul;42(7):3381-3387. doi: 10.21873/anticanres.15825.

Authors

Meng-Feng Wu^{1

2

3}, Li-Hsiou Chen^{1

4}, Ning-Yi Hsia⁵, Yi-Cheng Shen^{1

2}, Te-Chun Shen^{1

2}, Zhi-Hong Wang⁶, Ya-Chen Yang⁶, Yun-Chi Wang^{1

2}, Wen-Shin Chang^{1

2}, Te-Chun Hsia^{2

7

8}, DA-Tian Bau^{9

2

10}, Chia-Wen Tsai^{1

2}

Affiliations

¹ Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
² Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
³ Division of Chest Surgery, Department of Surgery, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, R.O.C.
⁴ Division of Chest Medicine, Department of Internal Medicine, Taichung Tzu Chi Hospital, Taichung, Taiwan, R.O.C.
⁵ Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan, R.O.C.
⁶ Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.
⁷ Department of Respiratory Therapy, China Medical University, Taichung, Taiwan, R.O.C.
⁸ Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C.
⁹ Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; artbau2@gmail.com wenwne816@gmail.com derrick@gmail.com.
¹⁰ Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.

PMID: 35790262
DOI: 10.21873/anticanres.15825

Abstract

Background/aim: The elevated expression of interleukin-18 (IL-18) among lung cancer patients raised our curiosity to examine the role of IL-18 genotypes in lung cancer.

Materials and methods: IL-18 -656 (rs1946519), -607 (rs1946518), and -137 (rs187238) genotypes of 358 lung cancer cases and 716 controls were determined via the PCR-RFLP methodology.

Results: The distributions of genotypic and allelic frequencies of IL-18 -607, but not those of -656 or -137, were differentially distributed between cases and controls. IL-18 -607 AC and CC genotypes were both lower (45.8% and 16.2%) in lung cancer patients compared to controls (51.4% and 24.7%). In addition, IL-18 -607 AC and CC genotypes were of significantly lower percentages both among non-smokers and smokers. Otherwise, no differential distribution was found regarding IL-18 -656 or -137.

Conclusion: IL-18 -607 C allele can serve as a protective predictor for lung cancer risk in Taiwanese.

Keywords: Genotype; Taiwan; interleukin-18; lung cancer; polymorphism; smoking.

MeSH terms

Genetic Predisposition to Disease
Genotype
Humans
Interleukin-18* / genetics
Lung Neoplasms* / genetics
Polymorphism, Single Nucleotide

Substances

Interleukin-18