The Burden of Diabetes-Related Chronic Kidney Disease in China From 1990 to 2019

Xiaowen Pan; Xiling Lin; Xin Huang; Jingya Xu; Lingxia Ye; Tianyue Zhang; Shaoning Hu; Hongwei Jiang; Yuezhong Ren; Peng-Fei Shan

doi:10.3389/fendo.2022.892860

The Burden of Diabetes-Related Chronic Kidney Disease in China From 1990 to 2019

Front Endocrinol (Lausanne). 2022 Jun 15:13:892860. doi: 10.3389/fendo.2022.892860. eCollection 2022.

Authors

Xiaowen Pan¹, Xiling Lin¹, Xin Huang¹, Jingya Xu¹, Lingxia Ye¹, Tianyue Zhang¹, Shaoning Hu¹, Hongwei Jiang², Yuezhong Ren¹, Peng-Fei Shan^{1

3}

Affiliations

¹ Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
² Endocrine and Metabolic Disease Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology; Medical Key Laboratory of Hereditary Rare Diseases of Henan; Luoyang Sub-Center of National Clinical Research Center for Metabolic Diseases, Luoyang, China.
³ Binjiang Institute of Zhejiang University, Hangzhou, China.

Abstract

Objective: To analyze the trends in disease burden of diabetes-related chronic kidney disease (CKD) by year, age, gender and types of diabetes in China from 1990 to 2019.

Methods: Data on prevalence, deaths and disability-adjusted life years (DALYs) for diabetes-related CKD were extracted from the Global Burden of Disease (GBD) 2019 study. Analyses were performed by year, age, gender and types of diabetes.

Results: In China, the numbers of deaths and DALYs of diabetes-related CKD continuously increased but the age-standardized rates (per 100,000 population) decreased over 30 years, in which the numbers of deaths and DALYs attributable to type 1 diabetes mellitus (T1DM)-related CKD barely changed and the age-standardized rates decreased over the years; and the number of deaths and DALYs attributable to type 2 diabetes mellitus (T2DM)-related CKD continuously increased, but the age-standardized rates also decreased. In 2019, 76.03 (58.24-95.61) thousand deaths and 2.13 (1.65-2.67) million DALYs were attributable to diabetes-related CKD, of which, T2DM accounted for 83.32% and 77.0% respectively, and T1DM accounted for the rest. Increasing gender disparity was seen, with males being more heavily impacted. The burden of diabetes-related CKD varied among different age groups, with the numbers of deaths and DALYs attributable to T1DM-related CKD peaking between 45 and 54 years of age and T2DM-related CKD peaking between 75 and 79 years of age; and the crude rates of deaths and DALYs attributable to T1DM-related CKD peaking between 70 and 79 years of age and 40 to 54 years of age, respectively, and T2DM-related CKD peaking over 90 years of age. Among neighboring and G20 countries, the burden of diabetes-related CKD in China was relatively controlled reflected by the ranking of adjusted death and DALYs rates.

Conclusions: The burden of diabetes-related CKD in China worsens and shows gender disparities and different age distribution. Greater efforts are needed to improve the health outcomes of these patients, especially among males.

Keywords: China; chronic kidney disease; death; diabetes; disability-adjusted life years.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged, 80 and over
China / epidemiology
Diabetes Mellitus, Type 1* / complications
Diabetes Mellitus, Type 1* / epidemiology
Diabetes Mellitus, Type 2* / complications
Diabetes Mellitus, Type 2* / epidemiology
Humans
Infant
Male
Quality-Adjusted Life Years
Renal Insufficiency, Chronic* / epidemiology
Renal Insufficiency, Chronic* / etiology