Blood Lead and High-Density Lipoprotein Concentrations in Relation to Human Blood Pressure: A Cross Sectional Study

Biao Hu; Pei-Yao He; Nan-Nan Zhong; Zi-Min Gao; Jiang-Long Guo; Jun-Tao Feng; Chu-Qin Huang; Jun-Bo Yang; Dong-Lin Sun

doi:10.3389/fnut.2022.899780

Blood Lead and High-Density Lipoprotein Concentrations in Relation to Human Blood Pressure: A Cross Sectional Study

Front Nutr. 2022 Jun 15:9:899780. doi: 10.3389/fnut.2022.899780. eCollection 2022.

Authors

Biao Hu¹, Pei-Yao He², Nan-Nan Zhong¹, Zi-Min Gao³, Jiang-Long Guo³, Jun-Tao Feng³, Chu-Qin Huang⁴, Jun-Bo Yang^{5

6}, Dong-Lin Sun⁷

Affiliations

¹ Department of Clinical Medicine, The Second Clinical School of Guangzhou Medical University, Guangzhou, China.
² Department of Anesthesiology, The Second Clinical School of Guangzhou Medical University, Guangzhou, China.
³ Department of Medical Imaging, The Second Clinical School of Guangzhou Medical University, Guangzhou, China.
⁴ State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
⁵ Department of Gastrointestinal Surgery, The Second Affiliated Hospital School of Medicine, Southern University of Science and Technology, Shenzhen, China.
⁶ Shenzhen Third People's Hospital, Shenzhen, China.
⁷ Guangzhou Medical University, Guangzhou, China.

Abstract

Background: While the relationship between blood pressure and blood lead has been studied more extensively, the effect of high-density lipoprotein (HDL) concentration on this relationship remains uncertain. Therefore, this study aimed to determine the effect of HDL concentration on the relationship between blood lead and blood pressure.

Methods: The research used cross-sectional data from the 2005 to 2014 National Health and Nutrition Examination Survey (NHANES), which included 16,451 participants aged 20-60 years. Multivariable linear regression was used to evaluate the correlation among blood lead, systolic blood pressure (SBP), and diastolic blood pressure (DBP). HDL concentration was determined by low HDL concentration (≤ 49 mg/dl) and high HDL concentration (>49 mg/dl) stratified. The effect of HDL concentration was assessed by an interaction test between blood lead and SBP in multivariable linear regression.

Results: In this cross-sectional research, we identified a positive correlation between blood lead and SBP, but not DBP. The relationship between blood lead and SBP was different in the group with low and high HDL concentrations (β: 0.21 95% Cl:-0.05-0.46 vs. β:0.47 95% Cl: 0.15-0.79). In addition, high HDL significantly altered the positive correlation between blood lead and SBP (P-value of interaction < 0.001).

Conclusion: The study suggests an interaction between HDL and blood lead in elevating SBP, which may have important clinical implications.

Keywords: HDL; blood lead; blood pressure; cross sectional study; interaction.