Maresin-1 and its receptors RORα/LGR6 as potential therapeutic target for respiratory diseases

Mengmeng Zhao; Chenfei Li; Jishou Zhang; Zheng Yin; Zihui Zheng; Jun Wan; Menglong Wang

doi:10.1016/j.phrs.2022.106337

Maresin-1 and its receptors RORα/LGR6 as potential therapeutic target for respiratory diseases

Pharmacol Res. 2022 Aug:182:106337. doi: 10.1016/j.phrs.2022.106337. Epub 2022 Jun 30.

Authors

Mengmeng Zhao¹, Chenfei Li¹, Jishou Zhang¹, Zheng Yin¹, Zihui Zheng¹, Jun Wan², Menglong Wang³

Affiliations

¹ Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China; Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China; Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China.
² Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China; Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China; Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China. Electronic address: wanjun@whu.edu.cn.
³ Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China; Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China; Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China. Electronic address: whuwangmenglong@163.com.

PMID: 35781060
DOI: 10.1016/j.phrs.2022.106337

Abstract

Maresin-1 is one of the representative specialized pro-resolving mediators that has shown beneficial effects in inflammatory disease models. Recently, two distinct types of receptor molecules were discovered as the targets of maresin-1, further revealing the pro-resolution mechanism of maresin-1. One is retinoic acid-related orphan receptor α (RORα) and the another one is leucine-rich repeat domain-containing G protein-coupled receptor 6 (LGR6). In this review, we summarized the detailed role of maresin-1 and its two different receptors in respiratory diseases. RORα and LGR6 are potential targets for the treatment of respiratory diseases. Future basic research and clinical trials on MaR1 and its receptors should provide useful information for the treatment of respiratory diseases.

Keywords: LGR6; Maresin-1; RORα; Resolution; Respiratory diseases.

Publication types

Review