Put out the fire: The pleiotropic anti-inflammatory action of non-vitamin K oral anticoagulants

Vincenzo Russo; Dario Fabiani

doi:10.1016/j.phrs.2022.106335

Put out the fire: The pleiotropic anti-inflammatory action of non-vitamin K oral anticoagulants

Pharmacol Res. 2022 Aug:182:106335. doi: 10.1016/j.phrs.2022.106335. Epub 2022 Jun 30.

Authors

Vincenzo Russo¹, Dario Fabiani²

Affiliations

¹ Cardiology Unit, Department of Medical Translational Sciences, University of Campania "Luigi Vanvitelli" - Monaldi Hospital, Naples, Italy. Electronic address: vincenzo.russo@unicampania.it.
² Cardiology Unit, Department of Medical Translational Sciences, University of Campania "Luigi Vanvitelli" - Monaldi Hospital, Naples, Italy.

PMID: 35781059
DOI: 10.1016/j.phrs.2022.106335

Abstract

Non-vitamin K antagonist oral anticoagulants (NOACs) should be the preferred anticoagulant strategy for preventing ischemic stroke in patients with atrial fibrillation (AF) at increased thromboembolic risk and for treating deep venous thromboembolism (DVT) in the general population. Beyond their inhibiting action on the activated factor X (FXa) or thrombin (FIIa), NOACs showed some pleiotropic anti-inflammatory effects. The present review aimed to describe the role of FXa and FIIa in the inflammation pathway and the potential anti-inflammatory effects of NOACs.

Keywords: Anti-inflammatory effects; Atherogenesis; Inflammation; Non-vitamin K antagonist oral anticoagulants; Vascular calcifications; Vitamin K antagonist.

Publication types

Review

MeSH terms

Administration, Oral
Anti-Inflammatory Agents / pharmacology
Anti-Inflammatory Agents / therapeutic use
Anticoagulants / adverse effects
Atrial Fibrillation* / drug therapy
Humans
Stroke* / drug therapy
Thromboembolism* / chemically induced

Substances

Anti-Inflammatory Agents
Anticoagulants