Terahertz meta-biosensor based on high-Q electrical resonance enhanced by the interference of toroidal dipole

Chiben Zhang; Tingjia Xue; Jin Zhang; Zhenfei Li; Longhai Liu; Jianhua Xie; Jianquan Yao; Guangming Wang; Xiaodan Ye; Weiren Zhu

doi:10.1016/j.bios.2022.114493

Terahertz meta-biosensor based on high-Q electrical resonance enhanced by the interference of toroidal dipole

Biosens Bioelectron. 2022 Oct 15:214:114493. doi: 10.1016/j.bios.2022.114493. Epub 2022 Jun 27.

Authors

Chiben Zhang¹, Tingjia Xue², Jin Zhang³, Zhenfei Li³, Longhai Liu⁴, Jianhua Xie⁵, Jianquan Yao⁶, Guangming Wang⁷, Xiaodan Ye⁸, Weiren Zhu⁹

Affiliations

¹ Department of Electronic Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China; Air and Missile Defense College, Air Force Engineering University, 710051, Xi'an, China.
² Department of Radiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.
³ Department of Electronic Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
⁴ Advantest (China) Co., Ltd. Shanghai, 201203, China; College of Precision Instruments and Opto-Electronics Engineering, Institute of Laser and Optoelectronics, Tianjin University, Tianjin, 300072, China.
⁵ Advantest (China) Co., Ltd. Shanghai, 201203, China.
⁶ College of Precision Instruments and Opto-Electronics Engineering, Institute of Laser and Optoelectronics, Tianjin University, Tianjin, 300072, China.
⁷ Air and Missile Defense College, Air Force Engineering University, 710051, Xi'an, China. Electronic address: wgming01@sina.com.
⁸ Department of Radiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China; Department of Radiology, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. Electronic address: yuanyxd@163.com.
⁹ Department of Electronic Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: weiren.zhu@sjtu.edu.cn.

PMID: 35780535
DOI: 10.1016/j.bios.2022.114493

Abstract

Electrical dipole resonances typically have low Q factor and broad resonant linewidth caused by strong free-space coupling with high radiative loss. Here, we present a strategy for enhancing the Q factor of the electrical resonance via the interference of a toroidal dipole. To validate such a strategy, a metasurface consisting of two resonators is designed that responsible to the electric and toroidal dipoles. According to constructive and destructive hybridizations of the two dipole modes, enhanced and decreased Q factors are found respectively for the two hybrid modes, compared to the one for the conventional electric dipole resonance. As a practical application of such high Q resonance, we further experimentally investigate the sensing performance of the metasurface biosensor by detecting the cell concentration of lung cancer cells (type A549). Moreover, through monitoring both resonance frequency and amplitude variation of the metasurface biosensor, the dielectric permittivity of the lung cancer cells is delicately estimated by the conjoint analysis of both simulated and measured results. Our proposed metasurface paves a promising way for the study of multipole interference in the field of nanophotonics and validates its effectiveness in biomedical sensing.

Keywords: Biosensing; Interference enhancement; Lung cancer detection; Metasurfaces; Terahertz.

MeSH terms

Biosensing Techniques*
Electricity
Humans
Lung Neoplasms*