Design, fabrication and testing of 3D printed smartphone-based device for collection of intrinsic fluorescence from human cervix

Sci Rep. 2022 Jul 1;12(1):11192. doi: 10.1038/s41598-022-15007-x.

Abstract

Fluorescence spectroscopy has the potential to identify discriminatory signatures, crucial for early diagnosis of cervical cancer. We demonstrate here the design, fabrication and testing of a 3D printed smartphone based spectroscopic device. Polarized fluorescence and elastic scattering spectra are captured through the device using a 405 nm laser and a white LED source respectively. The device has been calibrated by comparison of spectra of standard fluorophores (Flavin adenine dinucleotide, fluorescein, rhodamine, and porphyrin) with the corresponding spectra collected from a commercial spectrometer. A few cervical tissue spectra have also been captured for proof of its applicability as a portable, standalone device for the collection of intrinsic fluorescence spectra from human cervix.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cervix Uteri* / chemistry
  • Female
  • Humans
  • Printing, Three-Dimensional
  • Smartphone
  • Spectrometry, Fluorescence / methods
  • Uterine Cervical Neoplasms* / diagnosis