Relationship between vitamin D receptor gene polymorphisms and second acid-fast bacilli smear-positive during treatment for tuberculosis patients

Xiaoxu Zhang; Yan Zhang; Zhe Yin; Wenjun Xia; Hongkai Mao; Liangliang Bao; Yajie Liu; Mingqin Cao

doi:10.1016/j.meegid.2022.105324

Relationship between vitamin D receptor gene polymorphisms and second acid-fast bacilli smear-positive during treatment for tuberculosis patients

Infect Genet Evol. 2022 Sep:103:105324. doi: 10.1016/j.meegid.2022.105324. Epub 2022 Jun 28.

Authors

Xiaoxu Zhang¹, Yan Zhang¹, Zhe Yin¹, Wenjun Xia¹, Hongkai Mao¹, Liangliang Bao¹, Yajie Liu², Mingqin Cao³

Affiliations

¹ Department of epidemiology and health statistics, School of public health, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China.
² Medical record room, Xinjiang Medical University Affiliated Third Hospital, Urumqi, Xinjiang Uygur Autonomous Region, China.
³ Department of epidemiology and health statistics, School of public health, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China. Electronic address: cmq66@126.com.

PMID: 35777530
DOI: 10.1016/j.meegid.2022.105324

Abstract

Purpose: Tuberculosis (TB) treatment is associated with Vitamin D. This study aimed to explore the relationship between Vitamin D receptor (VDR) gene polymorphisms and second acid-fast bacilli (AFB) smear-positive during treatment for TB patients.

Methods: This was a cross-sectional study. Seven hundred and thirty-one TB patients whose single nucleotide polymorphism site (SNPs) of VDR gene were detected from December 2019 to December 2020 in XinJiang of China. The genotypic distributions in each group were tested separately for Hardy-Weinberg equilibrium. The tetragram test was used to construct haplotypes to evaluate the association between each haplotype and second AFB smear-positive occurrence.

Results: No significant deviations were observed with all the four polymorphism sites in the genotypic distributions (P>0.05). Linkage disequilibrium (LD) analysis showed that there was LD between SNPs of VDR gene (r²=0.74, D`>0.9). Each haplotype was not considered to be the influencing factor of second AFB smear-positive.

Conclusions: There is no association between VDR gene polymorphism (ApaI, BsmI, FokI and TaqI) and second AFB smear-positive.

Keywords: Haplotypes; Tuberculosis (TB); Vitamin D receptor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Cross-Sectional Studies
Gene Frequency
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Polymorphism, Single Nucleotide
Receptors, Calcitriol* / genetics
Tuberculosis* / drug therapy
Tuberculosis* / genetics
Vitamin D

Substances

Receptors, Calcitriol
VDR protein, human
Vitamin D