Structure-activity relationship in advanced glycation end products formation inhibitory activity of phlorotannins

Mitsuhiro Sekiguchi; Seiya Shinoda; Arisa Uno; Tomoya Masaki; Tetsuya Sasaki; Haruaki Ishiyama

doi:10.1093/bbb/zbac106

Structure-activity relationship in advanced glycation end products formation inhibitory activity of phlorotannins

Biosci Biotechnol Biochem. 2022 Aug 24;86(9):1207-1210. doi: 10.1093/bbb/zbac106.

Authors

Mitsuhiro Sekiguchi¹, Seiya Shinoda¹, Arisa Uno¹, Tomoya Masaki¹, Tetsuya Sasaki², Haruaki Ishiyama³

Affiliations

¹ Faculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University, Nonoichi, Ishikawa, Japan.
² Chemistry/Food Department, Industrial Research Institute of Ishikawa, Kanazawa, Ishikawa, Japan.
³ School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima, Japan.

PMID: 35776953
DOI: 10.1093/bbb/zbac106

Abstract

The structure and inhibitory activity of advanced glycation end products (AGEs) formation were studied using six model compounds and seven phlorotannins isolated from brown alga Ecklonia stolonifera. As a result, it was inferred that AGEs formation inhibitory activity was stronger when electron-rich groups were present because of the addition of many oxygen atoms to the phlorotannins.

Keywords: Ecklonia stolonifera; advanced glycation end products; phlorotannin.

MeSH terms

Dioxins* / chemistry
Dioxins* / pharmacology
Glycation End Products, Advanced
Phaeophyceae* / chemistry
Structure-Activity Relationship

Substances

Dioxins
Glycation End Products, Advanced