Modulation of Cell Energy Metabolism by the P2X7 Receptor

Francesco Di Virgilio; Simonetta Falzoni; Alba Clara Sarti; Paola Chiozzi; Valentina Vultaggio-Poma; Anna Lisa Giuliani

doi:10.1007/978-1-0716-2384-8_3

Modulation of Cell Energy Metabolism by the P2X7 Receptor

Methods Mol Biol. 2022:2510:53-63. doi: 10.1007/978-1-0716-2384-8_3.

Authors

Francesco Di Virgilio¹, Simonetta Falzoni², Alba Clara Sarti², Paola Chiozzi², Valentina Vultaggio-Poma², Anna Lisa Giuliani²

Affiliations

¹ Department of Medical Sciences, University of Ferrara, Ferrara, Italy. fdv@unife.it.
² Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

PMID: 35776319
DOI: 10.1007/978-1-0716-2384-8_3

Abstract

For many years the P2X7 receptor (P2X7R) was considered the prototypic cytolytic receptor due to its ability to cause dramatic changes in plasma membrane permeability, eventually leading to cell death. However, later studies revealed that controlled P2X7R activation has beneficial effects on cell metabolism and nowadays our perception of the physiological role of this receptor has radically changed. Some of the biochemical pathways underlying the trophic effect of the P2X7R are being unveiled, thus disclosing an unanticipated role of P2X7Rs in mitochondrial and glycolytic metabolism. We provide here an update of the effects of the P2X7R on cell energy metabolism.

Keywords: Extracellular ATP; Glycolysis; Mitochondria; P2X7.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Death / physiology
Cell Membrane Permeability
Glycolysis*
Mitochondria
Receptors, Purinergic P2X7* / genetics

Substances

Receptors, Purinergic P2X7