Mechanisms of SARS-CoV-2 Infection-Induced Kidney Injury: A Literature Review

Weihang He; Xiaoqiang Liu; Bing Hu; Dongshui Li; Luyao Chen; Yu Li; Yechao Tu; Situ Xiong; Gongxian Wang; Jun Deng; Bin Fu

doi:10.3389/fcimb.2022.838213

Mechanisms of SARS-CoV-2 Infection-Induced Kidney Injury: A Literature Review

Front Cell Infect Microbiol. 2022 Jun 14:12:838213. doi: 10.3389/fcimb.2022.838213. eCollection 2022.

Authors

Weihang He¹, Xiaoqiang Liu^{2

3}, Bing Hu², Dongshui Li¹, Luyao Chen², Yu Li², Yechao Tu², Situ Xiong², Gongxian Wang^{2

3}, Jun Deng², Bin Fu^{2

3}

Affiliations

¹ Reproductive Medicine Center, The First Affiliated Hospital of Nanchang University, Nanchang, China.
² Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
³ Jiangxi Institute of Urology, Nanchang, China.

Abstract

The severe acute respiratory coronavirus 2 (SARS-CoV-2) has become a life-threatening pandemic. Clinical evidence suggests that kidney involvement is common and might lead to mild proteinuria and even advanced acute kidney injury (AKI). Moreover, AKI caused by coronavirus disease 2019 (COVID-19) has been reported in several countries and regions, resulting in high patient mortality. COVID-19-induced kidney injury is affected by several factors including direct kidney injury mediated by the combination of virus and angiotensin-converting enzyme 2, immune response dysregulation, cytokine storm driven by SARS-CoV-2 infection, organ interactions, hypercoagulable state, and endothelial dysfunction. In this review, we summarized the mechanism of AKI caused by SARS-CoV-2 infection through literature search and analysis.

Keywords: ACE2; Acute kidney injury; COVID-19; SARS-CoV-2; TMPRSS2.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Acute Kidney Injury* / etiology
COVID-19* / complications
Humans
Kidney
Peptidyl-Dipeptidase A
SARS-CoV-2

Substances

Peptidyl-Dipeptidase A