Determination of Knockdown Resistance (kdr) Allele Frequencies (T929I mutation) in Head Louse Populations from Mexico, Canada, and Peru

Korean J Parasitol. 2022 Jun;60(3):217-221. doi: 10.3347/kjp.2022.60.3.217. Epub 2022 Jun 30.

Abstract

The head louse Pediculus humanus capitis (De Geer) is a hematophagous ectoparasite that inhabits the human scalp. The infestations are asymptomatic; however, skin irritation from scratching occasionally may cause secondary bacterial infections. The present study determined the presence and frequency of the knockdown resistance (kdr) mutation T929I in 245 head lice collected from Mexico, Peru, and Canada. Head lice were collected manually using a comb in the private head lice control clinic. Allele mutation at T9291 was present in 100% of the total sampled populations (245 lice) examined. In addition, 4.89% of the lice were homozygous susceptible, whereas 6.93% heterozygous and 88.16% homozygous were resistant, respectively. This represents the second report in Mexico and Quebec and fist in Lima.

Keywords: Pediculus humanus capitis; T929I; kdr.

MeSH terms

  • Animals
  • Canada
  • Gene Frequency
  • Humans
  • Insecticide Resistance / genetics
  • Insecticides* / pharmacology
  • Lice Infestations* / parasitology
  • Mexico
  • Mutation
  • Pediculus* / genetics
  • Peru
  • Vascular Endothelial Growth Factor Receptor-2 / genetics

Substances

  • Insecticides
  • KDR protein, human
  • Vascular Endothelial Growth Factor Receptor-2