Chewing Gums as a Drug Delivery Approach for Oral Health

Morteza Banakar; Sedigheh Moayedi; Erfan Shamsoddin; Zahra Vahedi; Mohammad Hasan Banakar; Seyyed Mojtaba Mousavi; Dinesh Rokaya; Kamran Bagheri Lankarani

doi:10.1155/2022/9430988

Chewing Gums as a Drug Delivery Approach for Oral Health

Int J Dent. 2022 Jun 20:2022:9430988. doi: 10.1155/2022/9430988. eCollection 2022.

Authors

Morteza Banakar^{1

2

3}, Sedigheh Moayedi⁴, Erfan Shamsoddin⁵, Zahra Vahedi⁶, Mohammad Hasan Banakar⁷, Seyyed Mojtaba Mousavi⁸, Dinesh Rokaya⁹, Kamran Bagheri Lankarani²

Affiliations

¹ Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
² Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
³ Department of Pediatric Dentistry, Faculty of Dentistry, Shahed University, Tehran, Iran.
⁴ Department of Orthodontics, Mashhad University of Medical Sciences, School of Dentistry, Mashhad, Iran.
⁵ Cochrane Iran Associate Centre, National Institute for Medical Research Development (NIMAD), Tehran, Iran.
⁶ School of Dentistry, Islamic Azad University Tehran Medical Sciences, Tehran, Iran.
⁷ School of Dentistry, Yasuj University of Medical Sciences, Yasuj, Iran.
⁸ Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
⁹ Department of Clinical Dentistry, Walailak University International College of Dentistry, Walailak University, Bangkok 10400, Thailand.

Abstract

Background: Drug delivery approaches with the shortest therapeutic period and the lowest side effects have always been considered a sublime target in the medical sciences. Among many delivery methods, chewing gum could be perceived as a promising drug carrier that can carry several types of drugs for oral health. These drug carriers could represent optimal therapeutic time and lower side effects due to their sustained release capability and lower required thresholds for the drug compared with other delivery approaches. The convenient use in the oral cavity's local environment and the ability to locally carry multiple drugs are considered the main advantages of this delivery approach.

Aim: This review aimed to explore chewing gum as a promising drug carrier that can carry several types of drugs for oral health.

Materials and methods: Articles were searched for on PubMed, ISI, SCOPUS, Google Patents, the Royal Society of Chemistry website, and electronic databases using MESH terms and the following keywords: ("Gum" OR "Chewing gum") and ("Drug delivery OR Drug delivery systems") in the English language. No time limit was applied, and all documents as of August 30th, 2020 were retrieved.

Results: Gum-drug interactions, mechanisms of release, and formulations of the drugs might all play a role in this versatile delivery method. Accordingly, chewing gum-based carriers may be presented as a plausible candidate for drug delivery in oral diseases.

Conclusion: Gum-driven drugs could be introduced as promising candidates for treating oral diseases due to their ability to deliver the proper local dosages of active ingredients, short contact time, biocompatibility, and biodegradable chemical structures.

Publication types

Review