Findings of in vitro Analyses of Basophil Functions May Help Us Better Understand Drug Desensitization

Masao Yamaguchi; Akiko Komiya; Maho Suzukawa; Rikiya Koketsu; Risa Shiragami; Motoyasu Iikura; Hiroyuki Nagase

doi:10.3389/falgy.2022.874772

Findings of in vitro Analyses of Basophil Functions May Help Us Better Understand Drug Desensitization

Front Allergy. 2022 Mar 30:3:874772. doi: 10.3389/falgy.2022.874772. eCollection 2022.

Authors

Masao Yamaguchi¹, Akiko Komiya², Maho Suzukawa³, Rikiya Koketsu⁴, Risa Shiragami¹, Motoyasu Iikura⁵, Hiroyuki Nagase⁶

Affiliations

¹ Division of Respiratory Medicine, Third Department of Medicine, Teikyo University Chiba Medical Center, Chiba, Japan.
² Department of Clinical Laboratory, National Hospital Organization Sagamihara National Hospital, Kanagawa, Japan.
³ Clinical Research Center, National Hospital Organization Tokyo National Hospital, Tokyo, Japan.
⁴ Department of Respiratory Medicine, Nishi-Kobe Medical Center, Hyogo, Japan.
⁵ Division of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan.
⁶ Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.

Abstract

Drug hypersensitivity can be an important problem during pharmacological management of various diseases. Patients diagnosed as having a drug allergy usually need to avoid the offending drug, either temporarily or for life. Another way of overcoming a drug allergy is to establish desensitization using the allergen drug itself. We previously investigated in vitro desensitization of human basophils using a subthreshold dose of an IgE-crosslinking reagent. We found that basophil desensitization occurred in a dose-dependent manner over a period of one to several hours. We think that inducible basophil desensitization occurring without histamine release may explain, at least in part, the clinical features of drug desensitization in type 1 drug allergy.

Keywords: IgE; anaphylaxis; basophil; cell activation; challenge test; desensitization.