Spatially-extended 3D magnetic DNA nanodevice-based split-type photoelectrochemical strategy for sensitive and reliable miRNA detection in cancer cells

Hui Yuan; Jiuming Sun; Qi Zhang; Mingyue Chu; Guiguang Cheng; Xia Li; Qingwang Xue

doi:10.1039/d2an00712f

Spatially-extended 3D magnetic DNA nanodevice-based split-type photoelectrochemical strategy for sensitive and reliable miRNA detection in cancer cells

Analyst. 2022 Jul 22;147(15):3415-3419. doi: 10.1039/d2an00712f.

Authors

Hui Yuan¹, Jiuming Sun¹, Qi Zhang¹, Mingyue Chu¹, Guiguang Cheng², Xia Li¹, Qingwang Xue¹

Affiliations

¹ Department of Chemistry, Liaocheng University, Liaocheng, 252059, Shandong, China. lixia@lcu.edu.cn.
² Faculty of Agriculture and Food, Kunming University of Science and Technology, Kunming, China.

PMID: 35766147
DOI: 10.1039/d2an00712f

Abstract

Highly sensitive and reliable PEC detection of miRNAs still faces some challenges like the inaccuracy caused by coexisting interferences in the PEC system. Herein, we developed a split-type "turn-off" PEC biosensor based on spatially-extended 3D magnetic DNA nanodevices with high-order DNA amplifiers for sensitive detection of miRNAs in cancer cells.

MeSH terms

Biosensing Techniques*
DNA / genetics
Electrochemical Techniques
Limit of Detection
Magnetic Phenomena
MicroRNAs* / genetics
Neoplasms* / diagnosis
Neoplasms* / genetics

Substances

MicroRNAs
DNA