Simple, rapid, and visual electrochemiluminescence sensor for on-site catechol analysis

Suhua Chen; Yuanyuan Lei; Junrong Xu; Yun Yang; Yiying Dong; Yanmei Li; Haomin Yi; Yilong Liao; Liyin Chen; Yi Xiao

doi:10.1039/d2ra03067e

Simple, rapid, and visual electrochemiluminescence sensor for on-site catechol analysis

RSC Adv. 2022 Jun 13;12(27):17330-17336. doi: 10.1039/d2ra03067e. eCollection 2022 Jun 7.

Authors

Suhua Chen¹, Yuanyuan Lei², Junrong Xu², Yun Yang², Yiying Dong², Yanmei Li², Haomin Yi², Yilong Liao², Liyin Chen², Yi Xiao^{2

3}

Affiliations

¹ Hunan Provincial Maternal and Child Health Care Hospital Changsha 410008 Hunan China njcpuxy4936@163.com.
² Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Department of Pharmacy, School of Medicine, Hunan Normal University Changsha 410013 Hunan China.
³ Experimental Soft Condensed Matter Group, School of Engineering and Applied Sciences, Harvard University Cambridge Massachusetts 02138 USA.

Abstract

Environmental pollution caused by aromatic compounds such as catechol (Cat) has become a major issue for human health. However, there is no simple, rapid, and low-cost method for on-site monitoring of Cat. Here, based on ECL quenching mechanism, we develop a simple, rapid and visual mesoporous silica (MSNs)-electrochemiluminescence (ECL) sensor for on-site monitoring of Cat. The mechanism of ECL quenching is due to the interaction between Cat and Ru(bpy)₃ ^2+* and the interactions between the oxidation products of Cat and DBAE. MSNs films with ordered perpendicular mesopore channels exhibit an amplification effect of ECL intensity due to the negatively charged pore channel. There is a good linear relationship between ECL intensity and Cat concentration in the range of 10 ∼ 1000 μM with the limit of detection (LOD) of 9.518 μM (R ² = 0.99). The on-site sensor is promising to offer new opportunities for pharmaceuticals analysis, on-site monitoring, and exposure risk assessment.