Single cell heterogeneity and evolution of breast cancer bone metastasis and organoids reveals therapeutic targets for precision medicine

K Ding; F Chen; N Priedigkeit; D D Brown; K Weiss; R Watters; K M Levine; T Heim; W Li; J Hooda; P C Lucas; J M Atkinson; S Oesterreich; A V Lee

doi:10.1016/j.annonc.2022.06.005

Single cell heterogeneity and evolution of breast cancer bone metastasis and organoids reveals therapeutic targets for precision medicine

Ann Oncol. 2022 Oct;33(10):1085-1088. doi: 10.1016/j.annonc.2022.06.005. Epub 2022 Jun 25.

Authors

K Ding¹, F Chen², N Priedigkeit³, D D Brown⁴, K Weiss⁵, R Watters⁶, K M Levine⁷, T Heim⁵, W Li⁸, J Hooda⁹, P C Lucas¹⁰, J M Atkinson¹¹, S Oesterreich¹², A V Lee¹³

Affiliations

¹ Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, USA; Integrative Systems Biology Program, University of Pittsburgh, Pittsburgh, USA.
² Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, USA; Tsinghua University, Beijing, China.
³ Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA.
⁴ Institute for Precision Medicine, University of Pittsburgh and UPMC, Pittsburgh, USA.
⁵ Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, USA; Musculoskeletal Oncology Laboratory, University of Pittsburgh, Pittsburgh, USA.
⁶ Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, USA; Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, USA; Musculoskeletal Oncology Laboratory, University of Pittsburgh, Pittsburgh, USA.
⁷ Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, USA.
⁸ Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, USA.
⁹ Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, USA.
¹⁰ Department of Pathology, University of Pittsburgh, Pittsburgh, USA.
¹¹ Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, USA; Institute for Precision Medicine, University of Pittsburgh and UPMC, Pittsburgh, USA.
¹² Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, USA. Electronic address: oesterreichs@upmc.edu.
¹³ Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, USA; Institute for Precision Medicine, University of Pittsburgh and UPMC, Pittsburgh, USA. Electronic address: leeav@upmc.edu.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Bone Neoplasms* / drug therapy
Bone Neoplasms* / genetics
Bone Neoplasms* / pathology
Breast Neoplasms* / drug therapy
Breast Neoplasms* / genetics
Breast Neoplasms* / pathology
Female
Humans
Organoids / pathology
Precision Medicine

Publication types

MeSH terms

Grants and funding