Confirmatory Virucidal Activity of Ionised Active Water S-100® on the SARS-CoV-2 Virus

Nathalie Wurtz; Issam Hasni; Audrey Bancod; Bernard La Scola

doi:10.1155/2022/5995775

Confirmatory Virucidal Activity of Ionised Active Water S-100® on the SARS-CoV-2 Virus

Adv Virol. 2022 Jun 17:2022:5995775. doi: 10.1155/2022/5995775. eCollection 2022.

Authors

Nathalie Wurtz^{1

2}, Issam Hasni², Audrey Bancod^{1

2}, Bernard La Scola^{1

2}

Affiliations

¹ Aix Marseille University, IRD, AP-HM, MEPHI, 13005 Marseille, France.
² Institut Hospitalo-Universitaire Méditerranée-Infection, 13005 Marseille, France.

Abstract

Ionised active water S-100® has been proposed as an original solution for use in dermocosmetics and for the treatment of wounds such as burns and atopic dermatitis. Among the mechanisms of action that are not completely understood, an antimicrobial activity would appear to be important. In the context of the COVID-19 pandemic, we assessed the inactivating efficacy of this solution on SARS-CoV-2 based on the recommendations of the NF-EN-14476+A2 standard. The tests carried out demonstrated that ionised active water S-100® 40% has a virucidal activity on SARS-CoV-2 which is at least 3.1 log after a contact time of 30 seconds and 3.5 log after two minutes at 20°C under clean conditions. Assays were also performed at 4°C and 37°C, and the results obtained are identical to those obtained at 20°C. This demonstration of the virucidal effect of ionised water against SARS-CoV-2 paves the way for the development of usage as an alternative disinfectant in SARS-CoV-2 control.