2-methoxy-4-(((5-nitropyridin-2-yl)imino)methyl)phenol Schiff base ligand and its Cu(II) and Zn(II) complexes: synthesis, characterization and biological investigations

P Deepika; H M Vinusha; Muneera Begum; Ramith Ramu; Prithvi S Shirahatti; M N Nagendra Prasad

doi:10.1016/j.heliyon.2022.e09648

2-methoxy-4-(((5-nitropyridin-2-yl)imino)methyl)phenol Schiff base ligand and its Cu(II) and Zn(II) complexes: synthesis, characterization and biological investigations

Heliyon. 2022 Jun 6;8(6):e09648. doi: 10.1016/j.heliyon.2022.e09648. eCollection 2022 Jun.

Authors

P Deepika¹, H M Vinusha², Muneera Begum¹, Ramith Ramu³, Prithvi S Shirahatti⁴, M N Nagendra Prasad⁵

Affiliations

¹ Department of Chemistry, JSS Science and Technology University, Mysuru, Karnataka, 570 006, India.
² PG Department of Chemistry, Sarada Vilas College, Mysuru, 570004, India.
³ Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research (JSS AHER), Mysuru, 570015, India.
⁴ Post Graduation Department of Biotechnology, Teresian College, Siddhartha Nagara, Mysuru, 570015, India.
⁵ Department of Biotechnology, JSS Science and Technology University, JSS Technical Institutional Campus, Mysuru, Karnataka, 570006, India.

Abstract

In this current work we have prepared a Schiff base ligand, (HL) derived from 5- nitropyridine-2-amine with 4-hydroxy-3-methoxybenzaldehyde and its Cu(II), and Zn(II) in 2:1 stoichiometric ratio (2HL:M). The formation of the ligand and the metal complexes were evaluated by means of MS, FT-IR, UV-Visible, ¹H-NMR, ¹³C-NMR and thermogravimetric methods. The free radical scavenging activity of compounds was evaluated through a sequence of in vitro assays viz., DPPH, ABTS and Superoxide where BHA was used as a positive controller. In vitro α-glucosidase inhibitory activities showed that complexes had considerable inhibitory potential when compared to the ligand.

Keywords: Antioxidant; Metal complexes; Pyridine based ligand; TG and DTG.