Mania as a Rare Adverse Event Secondary to Steroid Eye Drops

Moayyad Alsalem; Majed A Alharbi; Rayan A Alshareef; Raghad Khorshid; Salman Thabet; Abdulrahman Alghamdi

doi:10.1155/2022/4456716

Mania as a Rare Adverse Event Secondary to Steroid Eye Drops

Case Rep Psychiatry. 2022 Jun 16:2022:4456716. doi: 10.1155/2022/4456716. eCollection 2022.

Authors

Moayyad Alsalem^{1

2

3}, Majed A Alharbi^{4

5}, Rayan A Alshareef⁶, Raghad Khorshid^{1

2

3}, Salman Thabet^{1

2

3}, Abdulrahman Alghamdi^{1

2

3}

Affiliations

¹ Psychiatry Section, Department of Medicine, King Abdulaziz Medical City, Ministry of the National Guard-Health Affairs, Jeddah, Saudi Arabia.
² King Abdullah International Medical Research Center, Jeddah, Saudi Arabia.
³ College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
⁴ Department of Adult Mental Health, King Abdulaziz Medical City, Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia.
⁵ King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
⁶ Department of Ophthalmology, King Abdulaziz University, Jeddah, Saudi Arabia.

Abstract

Since glucocorticoids (GCs) were introduced for the treatment of various diseases, they have been linked with the development of psychiatric adverse effects such as mania, depression, and psychosis. These behavioral or psychiatric adverse events usually appear within a few days after commencing GCs and are possibly to reverse with drug withdrawal. We present a rare case of a 75-year-old woman who developed mania during treatment with GC eye drops following cataract surgery. Management consisted of discontinuing prednisolone and administering olanzapine, which resulted in full recovery in a week. Olanzapine was then discontinued, and a diagnosis of steroid-induced mania was concluded for this case.

Publication types

Case Reports