Molecular and clinical characteristics of carbapenem-resistant Enterobacteriaceae isolates collected at a tertiary hospital in northern China

Trans R Soc Trop Med Hyg. 2023 Jan 3;117(1):55-57. doi: 10.1093/trstmh/trac059.

Abstract

Background: Carbapenem-resistant Enterobacteriaceae (CRE) represent a severe public health problem.

Methods: In a tertiary hospital in northern China, 169 non-duplicated clinical CRE strains were analyzed by species identification, in vitro antibiotics sensitivity test, carbapenemase gene detection and genetic sequence typing.

Results: The CRE strains showed high resistance to most clinical antimicrobials. Enterobacter cloacae and Escherichia coli isolates mainly carried blaNDM, and Klebsiella pneumoniae isolates mainly carried blakpc. ST11 was the most common type in Klebsiella pneumoniae, and ST70 was the new emerging sequence type (ST) in Enterobacter cloacae.

Conclusions: The CRE strains isolated in northern China showed multidrug-resistant phenotypes, and the new emergence of ST70 Enterobacter cloacae should be closely supervised.

Keywords: antibiotics; carbapenem-resistant Enterobacteriaceae; carbapenemase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Proteins / genetics
  • Carbapenem-Resistant Enterobacteriaceae* / genetics
  • Carbapenems / pharmacology
  • Carbapenems / therapeutic use
  • China / epidemiology
  • Enterobacter cloacae / genetics
  • Enterobacteriaceae Infections* / drug therapy
  • Enterobacteriaceae Infections* / epidemiology
  • Escherichia coli
  • Humans
  • Klebsiella pneumoniae / genetics
  • Microbial Sensitivity Tests
  • Tertiary Care Centers

Substances

  • Carbapenems
  • Anti-Bacterial Agents
  • Bacterial Proteins