Translational Significance of the LINE-1 Jumping Gene in Skeletal Muscle

Matthew A Romero; Petey W Mumford; Paul A Roberson; Shelby C Osburn; Kaelin C Young; John M Sedivy; Michael D Roberts

doi:10.1249/JES.0000000000000301

Translational Significance of the LINE-1 Jumping Gene in Skeletal Muscle

Exerc Sport Sci Rev. 2022 Oct 1;50(4):185-193. doi: 10.1249/JES.0000000000000301. Epub 2022 Jun 24.

Authors

Matthew A Romero¹, Petey W Mumford², Paul A Roberson³, Shelby C Osburn⁴, Kaelin C Young, John M Sedivy⁵, Michael D Roberts

Affiliations

¹ Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA.
² Department of Exercise Science, Lindenwood University, St. Charles, MO.
³ Department of Cellular and Molecular Physiology, College of Medicine, The Pennsylvania State University, Hershey, PA.
⁴ School of Kinesiology, Auburn University, Auburn, AL.
⁵ Department of Molecular, Cellular Biology and Biochemistry, Center on the Biology of Aging, Brown University, Providence, RI.

Abstract

Retrotransposons are gene segments that proliferate in the genome, and the Long INterspersed Element 1 (LINE-1 or L1) retrotransposon is active in humans. Although older mammals show enhanced skeletal muscle L1 expression, exercise generally reverses this trend. We hypothesize skeletal muscle L1 expression influences muscle physiology, and additional innovative investigations are needed to confirm this hypothesis.

MeSH terms

Animals
Exercise
Humans
Long Interspersed Nucleotide Elements*
Mammals / genetics
Muscle, Skeletal* / metabolism

Abstract

MeSH terms

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