Limitations of arterial partial pressure of oxygen to fraction of inspired oxygen ratio for the evaluation of donor lung function

Abstract

Background: Evaluation of donor lung function relies on the arterial oxygen partial pressure to inspired oxygen fraction ratio (PaO₂ /FiO₂ ) measurement. Hemodynamic, metabolic derangements, and therapeutic intervention occurring during brain dead observation may influence the evaluation of gas exchange.

Methods: We performed a mathematical analysis to explore the influence of the extrapulmonary determinants on the interpretation of PaO₂ /FiO₂ in the brain-dead donor and during Ex-Vivo Lung Perfusion (EVLP).

Results: High FiO₂ and increased mixed venous oxygen saturation, caused by increased delivery and reduced consumption of oxygen, raise the PaO₂ /FiO₂ despite substantial intrapulmonary shunt. Anemia does not modify the PaO₂ /FiO₂ -intrapulmonary shunt relationship. During EVLP, the reduced artero-venous difference in oxygen content increases the PaO₂ /FiO₂ without this corresponding to an optimal graft function, while the reduced perfusate oxygen-carrying capacity linearizes the PaO₂ /FiO₂ -intrapulmonary shunt relationship.

Conclusions: Adopting PaO₂ /FiO₂ to evaluate graft suitability for transplantation should account for extrapulmonary factors affecting its interpretation.

Keywords: ex vivo lung perfusion; intrapulmonary shunt; lung transplantation; mixed venous oxygen saturation; multiorgan donor.