Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy

Simon Schnebert; Maxime Goguet; Emilio J Vélez; Alexandra Depincé; Florian Beaumatin; Amaury Herpin; Iban Seiliez

doi:10.3390/cells11121945

Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy

Cells. 2022 Jun 16;11(12):1945. doi: 10.3390/cells11121945.

Authors

Simon Schnebert¹, Maxime Goguet¹, Emilio J Vélez¹, Alexandra Depincé², Florian Beaumatin¹, Amaury Herpin², Iban Seiliez¹

Affiliations

¹ E2S UPPA, INRAE, NUMEA, Université de Pau et des Pays de l'Adour, 64310 Saint-Pée-sur-Nivelle, France.
² UR1037 Laboratory of Fish Physiology and Genomics, Campus de Beaulieu, INRAE, F-35042 Rennes, France.

Abstract

Autophagy is a pleiotropic and evolutionarily conserved process in eukaryotes that encompasses different types of mechanisms by which cells deliver cytoplasmic constituents to the lysosome for degradation. Interestingly, in mammals, two different and specialized autophagic pathways, (i) the chaperone-mediated autophagy (CMA) and (ii) the endosomal microautophagy (eMI), both rely on the use of the same cytosolic chaperone HSPA8 (also known as HSC70) for targeting specific substrates to the lysosome. However, this is not true for all organisms, and differences exist between species with respect to the coexistence of these two autophagic routes. In this paper, we present an in-depth analysis of the evolutionary history of the main components of CMA and eMI and discuss how the observed discrepancies between species may contribute to improving our knowledge of these two functions and their interplays.

Keywords: CMA; HSC70; KFERQ; LAMP2A; chaperone-mediated autophagy; eMI; endosomal microautophagy; evolution.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Autophagy
Chaperone-Mediated Autophagy*
Lysosomes / metabolism
Macroautophagy
Mammals
Microautophagy

Grants and funding

This work was supported by (i) I-site E2S: Energy and Environmental Solutions from the University of Pau and Pays de l’Adour (S.S., PhD fellowship: UPPA contract 2020-11); (ii) La Communauté d’Agglomération Pays Basque (M.G., PhD fellowship: INRAE contract 00004643); (iii) FONDS EUROPEEN POUR LES AFFAIRES MARITIMES ET LA PECHE (VITASWEET project n°PFEA470019FA1000005). This work was additionally supported by the TUNESAL (Research Project- HAVBRUK2, PN: 294971) and AquaExcel3.0 (Grant Agreement No. 871108) projects to AH, AD and IS.