Medical tattooing is mostly known as a treatment option after breast reconstructive surgery. Nowadays, medical tattooing has a broader indication and can be used for treating port wine stains, scars, burns and transplanted skin. We present three patients with different indications for medical tattooing: one patient with a facial port wine stain, one patient with a scar after a thoracotomy, and a patient with a skin transplantation. They were all satisfied with the result. We discuss alternative treatment options, the treatment technique, the aftercare, and the follow-up of medical tattooing. Patients with facial port wine stains, scars, burns and skin transplants remain difficult to treat. We therefore recommend to apply medical tattooing in a broader spectrum of patients and to set up a multi-center study investigating the patient reported outcomes measures and the results of this treatment technique.