Establishment of Prognostic Signatures of N6-Methyladenosine-Related lncRNAs and Their Potential Functions in Hepatocellular Carcinoma Patients

Xianbin Wu; Zhejun Deng; Xiaomin Liao; Xianxian Ruan; Nanfang Qu; Lixing Pang; Xiaoyan Shi; Shanyu Qin; Haixing Jiang

doi:10.3389/fonc.2022.865917

Establishment of Prognostic Signatures of N6-Methyladenosine-Related lncRNAs and Their Potential Functions in Hepatocellular Carcinoma Patients

Front Oncol. 2022 Jun 6:12:865917. doi: 10.3389/fonc.2022.865917. eCollection 2022.

Authors

Xianbin Wu^{1

2}, Zhejun Deng¹, Xiaomin Liao¹, Xianxian Ruan¹, Nanfang Qu³, Lixing Pang², Xiaoyan Shi¹, Shanyu Qin¹, Haixing Jiang¹

Affiliations

¹ Department of Gastroenterology, The First Afliated Hospital of Guangxi Medical University, Nanning, China.
² Department of Gastroenterology, The Third Affifiliated Hospital of Guangxi Medical University, Nanning, China.
³ Department of Gastroenterology, Affiliated Hospital of Guilin Medical University, Guilin, China.

Abstract

N6-methyladenosine (m6a)-related mRNAs and lncRNAs have been explored for their functions in several cancers. The present study aimed to identify potential signatures of m6a-related lncRNAs in hepatocellular carcinoma (HCC). We downloaded the expression and clinical data from The Cancer Genome Atlas (TCGA) database. The interacted mRNAs and lncRNAs, prognosis-related lncRNAs, potential metabolic pathways of lncRNAs, immune infiltration of various cells, and CD274 (PD-L1) -related lncRNAs were analyzed. Then, in vitro experiments explored the role of AC012073.1 (LOC105377626) in HCC cell lines. We found that candidate 14 lncRNA signatures play functions in HCC maybe by affecting immune infiltration, cell cycle, Notch signaling pathway, etc. LncRNA AC012073.1 (LOC105377626) functions as oncogenic roles in affecting HCC prognosis.

Keywords: AC012073.1; M6A; hepatocellular carcinoma; lncRNA; prognostic signature.