Aim: Spine surgery has been gradually transitioning from the inpatient setting into ambulatory surgery centers (ASC) and as such, the safety of treating patients on an outpatient basis needs to be validated. Objective:In this study, we aimed to evaluate the safety of anterior cervical disc arthroplasty (CDA) performed in an ambulatory setting in an Eastern European population. All existing studies evaluating safety and efficiency of outpatient CDA have originated from high-volume ASCs from the USA. Methods:We retrospectively reviewed 103 consecutive patients who underwent outpatient CDA between January 2018 and February 2020 in order to assess the safety of outpatient single- and multi-level CDA procedures. Various operative data was collected, including adverse events. Results:One patient required reintervention for reposition of the implant, resulting in a reoperation rate of 0.97%. Of the total 149 levels treated, the risk of readmission per level treated was 0.67%. Other AEs included prolonged postoperative hoarseness (laryngeal nerve dysfunction) in two (1.94%) patients, which for one patient resolved within one year. There were no other cases of reintervention, hospital readmission, or postoperative emergency visits. Conclusion:To our knowledge, this is the first study to evaluate the safety of CDA in the ambulatory setting in an Eastern European population. Our data suggests that CDA may be considered safe in the outpatient setting in appropriately selected patients. The 30-day reintervention rate was 0.97%, while AE rate was 1.94%. The reoperation and AE rates were similar to or lower than the complication rates reported by large US outcome studies.