Management of Posterior Fossa Tumors in Adults Based on the Predictors of Postoperative Hydrocephalus

Chengda Zhang; Tingbao Zhang; Lingli Ge; Zhengwei Li; Jincao Chen

doi:10.3389/fsurg.2022.886438

Management of Posterior Fossa Tumors in Adults Based on the Predictors of Postoperative Hydrocephalus

Front Surg. 2022 Jun 1:9:886438. doi: 10.3389/fsurg.2022.886438. eCollection 2022.

Authors

Chengda Zhang^{1

2}, Tingbao Zhang¹, Lingli Ge³, Zhengwei Li¹, Jincao Chen¹

Affiliations

¹ Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
² Department of Neurosurgery, Affiliated Hospital of Hubei University of Medicine, First People's Hospital of Xiangyang, Xiangyang, China.
³ Department of Paediatrics, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Central Hospital of Xiangyang, Xiangyang, China.

Abstract

Objective: This study aims to identify the predictors of postoperative hydrocephalus in patients with posterior fossa tumors (PFTs) and guide the management of perioperative hydrocephalus.

Methods: We performed a single-institution, retrospective analysis of patients who underwent resection of PFTs in our department over a 10-year period (2011-2021). A total of 682 adult patients met the inclusion criteria and were divided into either a prophylactic external ventricular drainage (EVD) group or a nonprophylactic-EVD group. We analyzed data for the nonprophylactic-EVD group by univariate and multivariate analyses to identify predictors of postoperative acute hydrocephalus. We also analyzed all cases by univariate and multivariate analyses to determine the predictors of postoperative ventriculoperitoneal (VP) shunt placement.

Results: Tumor infiltrating the midbrain aqueduct [P = 0.001; odds ratio (OR) = 9.8], postoperative hemorrhage (P < 0.001; OR = 66.7), and subtotal resection (P = 0.006; OR = 9.3) were independent risk factors for postoperative EVD. Tumor infiltrating the ventricular system (P < 0.001; OR = 58.5) and postoperative hemorrhage (P < 0.001; OR = 28.1) were independent risk factors for postoperative VP shunt placement.

Conclusions: These findings may help promote more aggressive monitoring and earlier interventions for postoperative hydrocephalus in patients with PFTs.

Keywords: PFT; VP shunt; adult; evd; hydrocephalus.