The Key Role of RNA Modification in Breast Cancer

Yang Liu; Tong Zhu; Yi Jiang; Jiawen Bu; Xudong Zhu; Xi Gu

doi:10.3389/fcell.2022.885133

The Key Role of RNA Modification in Breast Cancer

Front Cell Dev Biol. 2022 Jun 1:10:885133. doi: 10.3389/fcell.2022.885133. eCollection 2022.

Authors

Yang Liu¹, Tong Zhu¹, Yi Jiang¹, Jiawen Bu¹, Xudong Zhu¹, Xi Gu¹

Affiliation

¹ Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.

Abstract

The modulation of the function and expression of epigenetic regulators of RNA modification has gradually become the hotspot of cancer research. Studies have shown that alteration of epigenetic modifications can promote the development and metastasis of breast cancer. This review highlights the progress in characterization of the link between RNA modification and the prognosis, carcinogenesis and treatment of breast cancer, which may provide a new theoretical basis for development of effective strategies for monitoring of breast cancer based on epigenetics.

Keywords: RNA modification; breast cancer; carcinogenesis; m6A; treatment.

Publication types

Review