Upper Limbs Muscle Co-contraction Changes Correlated With the Impairment of the Corticospinal Tract in Stroke Survivors: Preliminary Evidence From Electromyography and Motor-Evoked Potential

Wenfei Sheng; Shijue Li; Jiangli Zhao; Yujia Wang; Zichong Luo; Wai Leung Ambrose Lo; Minghui Ding; Chuhuai Wang; Le Li

doi:10.3389/fnins.2022.886909

Upper Limbs Muscle Co-contraction Changes Correlated With the Impairment of the Corticospinal Tract in Stroke Survivors: Preliminary Evidence From Electromyography and Motor-Evoked Potential

Front Neurosci. 2022 Jun 1:16:886909. doi: 10.3389/fnins.2022.886909. eCollection 2022.

Authors

Wenfei Sheng¹, Shijue Li¹, Jiangli Zhao¹, Yujia Wang², Zichong Luo², Wai Leung Ambrose Lo¹, Minghui Ding¹, Chuhuai Wang¹, Le Li³

Affiliations

¹ Department of Rehabilitation Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
² Faculty of Science and Technology, University of Macau, Taipa, Macao SAR, China.
³ Institute of Medical Research, Northwestern Polytechnical University, Xi'an, China.

Abstract

Objective: Increased muscle co-contraction of the agonist and antagonist muscles during voluntary movement is commonly observed in the upper limbs of stroke survivors. Much remain to be understood about the underlying mechanism. The aim of the study is to investigate the correlation between increased muscle co-contraction and the function of the corticospinal tract (CST).

Methods: Nine stroke survivors and nine age-matched healthy individuals were recruited. All the participants were instructed to perform isometric maximal voluntary contraction (MVC) and horizontal task which consist of sponge grasp, horizontal transportation, and sponge release. We recorded electromyography (EMG) activities from four muscle groups during the MVC test and horizontal task in the upper limbs of stroke survivors. The muscle groups consist of extensor digitorum (ED), flexor digitorum (FD), triceps brachii (TRI), and biceps brachii (BIC). The root mean square (RMS) of EMG was applied to assess the muscle activation during horizontal task. We adopted a co-contraction index (CI) to evaluate the degree of muscle co-contraction. CST function was evaluated by the motor-evoked potential (MEP) parameters, including resting motor threshold, amplitude, latency, and central motor conduction time. We employed correlation analysis to probe the association between CI and MEP parameters.

Results: The RMS, CI, and MEP parameters on the affected side showed significant difference compared with the unaffected side of stroke survivors and the healthy group. The result of correlation analysis showed that CI was significantly correlated with MEP parameters in stroke survivors.

Conclusion: There existed increased muscle co-contraction and impairment in CST functionality on the affected side of stroke survivors. The increased muscle co-contraction was correlated with the impairment of the CST. Intervention that could improve the excitability of the CST may contribute to the recovery of muscle discoordination in the upper limbs of stroke survivors.

Keywords: correlation analyses; corticospinal tract; motor-evoked potential; muscle co-contraction; stroke.