A concise review of the orofacial mesenchymal stromal cells as a novel therapy for neurological diseases and injuries

Zhili Dong; Liping Wu; Lu Zhao

doi:10.1002/term.3333

A concise review of the orofacial mesenchymal stromal cells as a novel therapy for neurological diseases and injuries

J Tissue Eng Regen Med. 2022 Sep;16(9):775-787. doi: 10.1002/term.3333. Epub 2022 Jun 18.

Authors

Zhili Dong^{1

2}, Liping Wu^{1

2}, Lu Zhao^{1

3}

Affiliations

¹ Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China.
² Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China.
³ South China Center of Craniofacial Stem Cell Research, Sun Yat-sen University, Guangzhou, Guangdong, China.

PMID: 35716051
DOI: 10.1002/term.3333

Abstract

Orofacial mesenchymal stromal cells (OFMSCs) are mesenchymal stromal cells isolated from the oral and facial regions, which possess typical mesenchymal stromal cell features such as self-renewing, multilineage differentiation, and immunoregulatory properties. Recently, increasing studies have been carried out on the neurotrophic and neuroregenerative properties of OFMSCs as well as their potential to treat neurological diseases. In this review, we summarize the current evidence and discuss the prospects regarding the therapeutic potential of OFMSCs as a new approach to treat different neurological diseases and injuries.

Keywords: cell transplantation; dental pulp stem cells; neurological diseases and injuries; orofacial mesenchymal stromal cells.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Differentiation
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells*
Nerve Regeneration