Comparing Serum Matrix Metalloproteinase-7 in Parenteral Nutrition-Associated Liver Disease and Biliary Atresia

Pooja S Salvi; Rima Fawaz; Robert A Cowles

doi:10.1016/j.jpeds.2022.06.014

Comparing Serum Matrix Metalloproteinase-7 in Parenteral Nutrition-Associated Liver Disease and Biliary Atresia

J Pediatr. 2022 Oct:249:97-100. doi: 10.1016/j.jpeds.2022.06.014. Epub 2022 Jun 14.

Authors

Pooja S Salvi¹, Rima Fawaz², Robert A Cowles³

Affiliations

¹ Department of Surgery, Division of Pediatric Surgery, Yale School of Medicine, New Haven, CT.
² Section of Pediatric Gastroenterology and Hepatology, Yale-New Haven Hospital, New Haven, CT.
³ Department of Surgery, Division of Pediatric Surgery, Yale School of Medicine, New Haven, CT. Electronic address: robert.cowles@yale.edu.

PMID: 35714967
DOI: 10.1016/j.jpeds.2022.06.014

Abstract

In this cross-sectional study, serum matrix metalloproteinase-7 levels were significantly lower in infants with jaundice and parenteral nutrition-associated liver disease compared with those with confirmed biliary atresia. Serum metalloproteinase-7 may aid in excluding biliary atresia and thus may minimize invasive testing in infants with a history of parenteral nutrition.

Keywords: biomarker; cholestasis; neonatal jaundice.

Publication types

Case Reports

MeSH terms

Biliary Atresia* / complications
Cholestasis* / complications
Cross-Sectional Studies
Humans
Infant
Liver
Liver Diseases* / complications
Matrix Metalloproteinase 7
Parenteral Nutrition / adverse effects

Substances

Matrix Metalloproteinase 7