In vitro anticancer properties of anthocyanins: A systematic review

Biochim Biophys Acta Rev Cancer. 2022 Jul;1877(4):188748. doi: 10.1016/j.bbcan.2022.188748. Epub 2022 Jun 14.

Abstract

Anthocyanins have been associated with beneficial effects on human health. Cancer has been one of the main public health issues due to its aggressiveness and high mortality rate. This systematic review aimed to address recent research (from January 2000 to September 2021) on the anticancer activity of anthocyanins assessed by in vitro assays. The selected studies revealed that anthocyanins have anticancer potential by inhibiting cancer cell viability and proliferation, controlling cell cycle, and promoting apoptosis.

Keywords: Anthocyanin; Antineoplastic; Antiproliferative; Apoptosis; Cell cycle; Protein expression.

Publication types

  • Review
  • Systematic Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthocyanins* / metabolism
  • Anthocyanins* / pharmacology
  • Anthocyanins* / therapeutic use
  • Apoptosis
  • Cell Proliferation
  • Cell Survival
  • Humans
  • Plant Extracts* / metabolism
  • Plant Extracts* / pharmacology

Substances

  • Anthocyanins
  • Plant Extracts