A Facile Approach for the Ligand Free Synthesis of Biocompatible Upconversion Nanophosphors

Abstract

Upconversion nanophosphors, particles that can absorb low energy radiation and emit high energy light through multi-photon absorption processes, have gained augmented attention in recent years. Due to their admirable optical and chemical properties, these nanoparticles are finding wide range of applications in the field of bioimaging, light emitting devices and security printing. However, for any practical application, it is extremely important that a facile synthetic route is developed that can lead to the generation of nanophosphors exhibiting efficient upconversion luminescence under diverse experimental conditions. Herein, we report a new ligand-free approach for the synthesis of lanthanide-based upconversion nanoparticles by adopting a simple solid-state synthetic route. The reaction conditions such as temperature and time were optimized to obtain nanophosphors exhibiting enhanced upconversion luminescence. The synthesized nanoparticles, due to its ligand-free nature, could be well dispersed in both aqueous and organic media. The nanophosphors retained the upconversion luminescence under varying time, pH and temperature, indicating that the absence of ligand had least effect on their stability. The nanophosphors were found to exhibit good cell viability even under high concentrations, unveiling their potential as bioimaging agents in the biomedical research.

Keywords: anti-Stokes shift; biocompatible nanoparticles; ligand free synthesis; two/multi-photon absorption; upconversion nanophosphors.