Potential intervariant and intravariant recombination of Delta and Omicron variants

Lulan Wang; Hang-Yu Zhou; Jia-Ying Li; Ye-Xiao Cheng; Shilei Zhang; Saba Aliyari; Aiping Wu; Genhong Cheng

doi:10.1002/jmv.27939

Potential intervariant and intravariant recombination of Delta and Omicron variants

J Med Virol. 2022 Oct;94(10):4830-4838. doi: 10.1002/jmv.27939. Epub 2022 Jul 9.

Authors

Lulan Wang¹, Hang-Yu Zhou^{2

3}, Jia-Ying Li^{2

3}, Ye-Xiao Cheng^{2

3

4}, Shilei Zhang¹, Saba Aliyari¹, Aiping Wu^{2

3}, Genhong Cheng¹

Affiliations

¹ Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, USA.
² Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
³ Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, China.
⁴ School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.

Abstract

Among numerous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concerns, Omicron is more infectious and immune-escaping, while Delta is more pathogenic. Here, we provide evidence for both intervariant and intravariant recombination of the rapidly evolving new SARS-CoV-2 genomes, including XD/XE/XF and BA.3, raising concerns of potential more infectious, immune-escaping, and disease-causing Omicron and Delta-Omicron variants.

Keywords: Delta-Omicron XD; Omicron; SARS-CoV-2; recombination.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

COVID-19*
Humans
Recombination, Genetic
SARS-CoV-2* / genetics

Supplementary concepts

SARS-CoV-2 variants

Abstract

Publication types

MeSH terms

Supplementary concepts

Grants and funding