Circulating IL-6 but not neutrophil extracellular traps levels can predict anakinra effectiveness in patients with severe COVID-19

J Leukoc Biol. 2022 Dec;112(6):1365-1367. doi: 10.1002/JLB.4LT0122-018RR. Epub 2022 Jun 15.

Vanessa Granger^{1

2}, Audrey Fels³, Thomas Huet⁴, Jean-Louis Laplanche⁵, Sophie Laplanche⁶, Gilles Chatellier³, Hélène Beaussier³, Sylvie Chollet-Martin^{1

2}, Luc de Chaisemartin^{1

2}, Gilles Hayem⁴

¹ Immunology Department, Bichat Hospital, APHP, DMU BIOGéM, Paris, France.
² Inserm, Inflammation, Microbiome and Immunosurveillance, Université Paris-Saclay, Châtenay-Malabry, France.
³ Clinical Research Department, Paris-Saint Joseph Hospital Group, Paris, France.
⁴ Rheumatology Department, Paris-Saint Joseph Hospital Group, Paris, France.
⁵ Biochemistry & Molecular Biology Department, Saint-Louis Lariboisière and Fernand-Widal Hospital Group, Paris, France.
⁶ Biology Department, Paris-Saint Joseph Hospital Group, Paris, France.

Abstract

Added data on circulating IL-6 levels can predict COVID-19 severity and IL1RA efficiency.