Extracellular Vesicles That Herald the Scarcity of Oxygen

Sekyung Oh; Sang-Ho Kwon

doi:10.1159/000524423

Extracellular Vesicles That Herald the Scarcity of Oxygen

Kidney Dis (Basel). 2022 Apr 22;8(3):202-205. doi: 10.1159/000524423. eCollection 2022 May.

Authors

Sekyung Oh¹, Sang-Ho Kwon²

Affiliations

¹ Department of Medical Science, Catholic Kwandong University College of Medicine, Incheon, Republic of Korea.
² Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.

Abstract

The natural, membrane-bound nanoscale particles, called extracellular vesicles (EVs) have emerged as an effective, versatile vehicle to transport desired drugs specifically to injury sites. Heralding the presence of the scarcity of oxygen, EVs produced from the cells upregulating the expression of the critical transcriptional regulator of hypoxia, HIF-1, can induce a response in ischemia-reperfusion-damaged cells to ameliorate renal tubular injury and inflammation.

Keywords: Exosomes; Extracellular vesicles; Hypoxia; Ischemia; Kidney injury.