Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer

Kerstin Rhiem; Bernd Auber; Susanne Briest; Nicola Dikow; Nina Ditsch; Neda Dragicevic; Sabine Grill; Eric Hahnen; Judit Horvath; Bernadette Jaeger; Karin Kast; Marion Kiechle; Elena Leinert; Susanne Morlot; Michael Püsken; Dieter Schäfer; Sarah Schott; Christopher Schroeder; Ulrike Siebers-Renelt; Christine Solbach; Nana Weber-Lassalle; Isabell Witzel; Christine Zeder-Göß; Rita K Schmutzler

doi:10.1159/000516376

Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer

Breast Care (Basel). 2022 Apr;17(2):199-207. doi: 10.1159/000516376. Epub 2021 Jul 19.

Authors

Kerstin Rhiem¹, Bernd Auber², Susanne Briest³, Nicola Dikow⁴, Nina Ditsch⁵, Neda Dragicevic⁶, Sabine Grill⁷, Eric Hahnen¹, Judit Horvath⁸, Bernadette Jaeger⁹, Karin Kast¹, Marion Kiechle⁷, Elena Leinert¹⁰, Susanne Morlot², Michael Püsken¹¹, Dieter Schäfer¹², Sarah Schott¹³, Christopher Schroeder¹⁴, Ulrike Siebers-Renelt⁸, Christine Solbach¹⁵, Nana Weber-Lassalle¹, Isabell Witzel¹⁶, Christine Zeder-Göß⁵, Rita K Schmutzler¹

Affiliations

¹ Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology, Cologne, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.
² Department of Human Genetics, Hannover Medical School, Hannover, Germany.
³ Department of Obstetrics and Gynaecology, University Hospital of Leipzig, Leipzig, Germany.
⁴ Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany.
⁵ Department of Gynecology and Obstetrics, University Hospital of Augsburg, Augsburg, Germany.
⁶ Institute of Human Genetics, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
⁷ Department of Gynecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technical University Munich (TUM), Munich, Germany.
⁸ Institute for Human Genetics, University Hospital Münster, Münster, Germany.
⁹ Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
¹⁰ Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany.
¹¹ Department of Radiology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.
¹² Institute for Human Genetics, University of Frankfurt, Frankfurt, Germany.
¹³ Department of Obstetrics and Gynaecology, University of Heidelberg, Heidelberg, Germany.
¹⁴ Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen, Tübingen, Germany.
¹⁵ Department of Gynecology and Obstetrics, University Hospital Frankfurt, Frankfurt, Germany.
¹⁶ Department of Obstetrics and Gynaecology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Abstract

Background: The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk®) for the analysis of risk genes for familial breast and ovarian cancer.

Summary: An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process.

Key messages: The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the centers of the GC-HBOC from the initial consultation prior to genetic testing to the use of individual risk-adapted preventive/therapeutic measures.

Keywords: BRCA1; BRCA2; Consensus; Hereditary breast cancer; Hereditary ovarian cancer; Panel testing.

Publication types

Review