Mutagenic repair during antibody diversification: emerging insights

Trends Immunol. 2022 Aug;43(8):604-607. doi: 10.1016/j.it.2022.05.004. Epub 2022 Jun 11.

Abstract

Deoxyuracils (dUs) produced by activation-induced cytidine deaminase (AID) during antibody diversification are processed by base excision repair (BER) and mismatch repair (MMR) pathways that paradoxically expand this lesion within jawed vertebrate immunoglobulin (Ig) genes. We highlight new findings describing mechanisms that allow B cells to carry out mutagenic DNA repair, an essential process for antibody maturation with implications in cancer pathogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies / genetics
  • Cytidine Deaminase* / genetics
  • Cytidine Deaminase* / metabolism
  • DNA Repair
  • Genes, Immunoglobulin
  • Humans
  • Immunoglobulin Class Switching / genetics
  • Mutagens*
  • Somatic Hypermutation, Immunoglobulin

Substances

  • Antibodies
  • Mutagens
  • Cytidine Deaminase

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