Minimalist O2 generator formed by in situ KMnO4 oxidation for tumor cascade therapy

Haiyan Pan; Quan Zou; Tingting Wang; Dong Li; Shao-Kai Sun

doi:10.1016/j.biomaterials.2022.121596

Minimalist O₂ generator formed by in situ KMnO₄ oxidation for tumor cascade therapy

Biomaterials. 2022 Aug:287:121596. doi: 10.1016/j.biomaterials.2022.121596. Epub 2022 Jun 7.

Authors

Haiyan Pan¹, Quan Zou², Tingting Wang³, Dong Li¹, Shao-Kai Sun⁴

Affiliations

¹ Department of Radiology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
² Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
³ Department of Ultrasound in Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, 310009, China.
⁴ School of Medical Imaging, Tianjin Medical University, Tianjin, 300203, China. Electronic address: shaokaisun@tmu.edu.cn.

PMID: 35700623
DOI: 10.1016/j.biomaterials.2022.121596

Abstract

Diverse oxygen generation strategies have been developed to overcome hypoxia in tumors for enhancing the therapeutic efficacy, but inevitably suffering from tedious synthesis process of oxygen generators in vitro before in vivo administration. Herein, we show direct injection of commercially and clinically used KMnO₄ into solid tumors enables in situ formation of MnO₂ as an oxygen depot for cascade oxidation damage and enhanced photodynamic therapy. KMnO₄ can damage tumor tissues by oxidation and generate MnO₂, and subsequent intravenous injection of Ce6 allows MnO₂-triggered hypoxia-modulated photodynamic therapy of tumors. Excellent cascade tumor suppression effect is realized both in vitro and in vivo based on the KMnO₄-Ce6 system without the need of synthesis. The proposed strategy lays down a novel way with unprecedented superiors of no need of synthesis process and ultra-facile administration procedure for tumor hypoxia-modulated cascade therapy.

Keywords: KMnO(4); O(2) generator; Oxidative damage; Photodynamic therapy.