Potential of MicroRNAs As Biomarkers and Therapeutic Targets in Respiratory Viruses: A Literature Review

DNA Cell Biol. 2022 Jun;41(6):544-563. doi: 10.1089/dna.2021.1101.

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression through recognition of cognate sequences and interference of transcriptional, translational, or epigenetic processes. Hundreds of miRNA genes have been found in diverse viruses, and many of these are phylogenetically conserved. Respiratory viruses are the most frequent causative agents of disease in humans, with a significant impact on morbidity and mortality worldwide. Recently, the role of miRNAs in respiratory viral gene regulation, as well as host gene regulation during disease progression, has become a field of interest. This review highlighted the importance of various miRNAs and their potential role in fighting with respiratory viruses as therapeutic molecules with a focus on COVID-19.

Keywords: COVID-19; microRNA; respiratory viruses.

Publication types

  • Review

MeSH terms

  • Biomarkers
  • COVID-19 / genetics
  • Gene Expression Regulation, Viral
  • Humans
  • MicroRNAs* / genetics
  • Respiratory Tract Diseases* / virology
  • Viruses* / genetics

Substances

  • Biomarkers
  • MicroRNAs