Study on repair of abdominal wall defect rats with hernia mesh coated with chitosan-based photosensitive hydrogel

Huiwen Hu; Huanchao Sun; Zhiwen Jiang; Shuo Wang; Chenqi Liu; Mingyu Zou; Ruibao Ju; Zhilong Feng; Wanshun Liu; Ting Wang; Baoqin Han

doi:10.1016/j.carbpol.2022.119577

Study on repair of abdominal wall defect rats with hernia mesh coated with chitosan-based photosensitive hydrogel

Carbohydr Polym. 2022 Sep 1:291:119577. doi: 10.1016/j.carbpol.2022.119577. Epub 2022 May 7.

Authors

Huiwen Hu¹, Huanchao Sun¹, Zhiwen Jiang¹, Shuo Wang¹, Chenqi Liu¹, Mingyu Zou¹, Ruibao Ju¹, Zhilong Feng¹, Wanshun Liu¹, Ting Wang², Baoqin Han³

Affiliations

¹ Laboratory of Biochemistry and Biomedical Materials, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, PR China.
² Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao 266003, PR China. Electronic address: wangting@qduhospital.cn.
³ Laboratory of Biochemistry and Biomedical Materials, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, PR China; Laboratory for Marine Drugs and Bioproducts of Pilot National Laboratory for Marine Science and Technology, Qingdao 266235, PR China. Electronic address: baoqinh@ouc.edu.cn.

PMID: 35698395
DOI: 10.1016/j.carbpol.2022.119577

Abstract

Herein, hydroxypropyl chitosan azide (AZ-HPCTS) was synthesized and prepared as a hydrogel coating applied to a polypropylene mesh (PPM) through UV irradiation. This study confirmed the hypothesis that hydrogels with porous three-dimensional network structures exhibited excellent biocompatibility and biodegradability and adhered well to PPM. During the 180-day follow-up period, the AZ-HPCTS-coated PPM (AH-PPM) promoted wound healing by promoting the secretion of transforming growth factor-beta1 (TGF-beta1) in the acute reaction stage, which was reduced to a lower level at 30 d. The PPM exhibited a lower fibrin lysozyme activity based on the expression of tissue plasminogen activator (tPA) compared with that of AH-PPM (P < 0.05). The intraperitoneal adhesion score of AH-PPM decreased to 2.4 at 180 d in contrast with PPM (P < 0.01), which remained at a high level throughout the study. In conclusion, the AZ-HPCTS hydrogel is a potential coating for hernia patches that deserves further study in the biomaterial field.

Keywords: Chitosan; Hernia repair; Hydrogel; Photosensitive.

MeSH terms

Abdominal Wall* / surgery
Animals
Chitosan* / chemistry
Hernia
Hydrogels / chemistry
Hydrogels / pharmacology
Polypropylenes / chemistry
Rats
Surgical Mesh
Tissue Plasminogen Activator

Substances

Hydrogels
Polypropylenes
Chitosan
Tissue Plasminogen Activator