A state-of-the-art review on fucoidan as an antiviral agent to combat viral infections

Biswajita Pradhan; Rabindra Nayak; Srimanta Patra; Prajna Paramita Bhuyan; Pradyota Kumar Behera; Amiya Kumar Mandal; Chhandashree Behera; Jang-Seu Ki; Siba Prasad Adhikary; Davoodbasha MubarakAli; Mrutyunjay Jena

doi:10.1016/j.carbpol.2022.119551

A state-of-the-art review on fucoidan as an antiviral agent to combat viral infections

Carbohydr Polym. 2022 Sep 1:291:119551. doi: 10.1016/j.carbpol.2022.119551. Epub 2022 May 2.

Affiliations

¹ Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, Odisha, India; Department of Biotechnology, Sangmyung University, Seoul 03016, Republic of Korea.
² Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, Odisha, India.
³ Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology Rourkela, Odisha, India.
⁴ Department of Botany, Maharaja Sriram Chandra Bhanja Deo University, Baripada 757003, Odisha, India.
⁵ Department of Chemistry, Berhampur University, Bhanja Bihar, Berhampur 760007, Odisha, India.
⁶ Department of Biotechnology, Sangmyung University, Seoul 03016, Republic of Korea.
⁷ Department of Biotechnology, Institute of Science, Visva-Bharati, Santiniketan 731235, West Bengal, India.
⁸ School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology, Chennai 600048, India. Electronic address: mubinano@gmail.com.
⁹ Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, Odisha, India. Electronic address: mrutyunjay.jena@gmail.com.

Abstract

As a significant public health hazard with several drug side effects during medical treatment, searching for novel therapeutic natural medicines is promising. Sulfated polysaccharides from algae, such as fucoidan, have been discovered to have a variety of medical applications, including antibacterial and immunomodulatory properties. The review emphasized on the utilization of fucoidan as an antiviral agent against viral infections by inhibiting their attachment and replication. Moreover, it can also trigger immune response against viral infection in humans. This review suggested to be use the fucoidan for the potential protective remedy against COVID-19 and addressing the antiviral activities of sulfated polysaccharide, fucoidan derived from marine algae that could be used as an anti-COVID19 drug in near future.

Keywords: Antiviral drug; COVID-19; Fucoidan; Immunomodulation; Marine algae.

Publication types

Review

MeSH terms

Antiviral Agents* / pharmacology
Antiviral Agents* / therapeutic use
COVID-19 Drug Treatment*
Humans
Polysaccharides / pharmacology
Polysaccharides / therapeutic use
Sulfates

Substances

Antiviral Agents
Polysaccharides
Sulfates
fucoidan