Illuminating RNA biology through imaging

Phuong Le; Noorsher Ahmed; Gene W Yeo

doi:10.1038/s41556-022-00933-9

Illuminating RNA biology through imaging

Nat Cell Biol. 2022 Jun;24(6):815-824. doi: 10.1038/s41556-022-00933-9. Epub 2022 Jun 13.

Authors

Phuong Le^{1

2

3}, Noorsher Ahmed^{1

2

3

4}, Gene W Yeo^{5

6

7

8}

Affiliations

¹ Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
² Stem Cell Program, University of California San Diego, La Jolla, CA, USA.
³ Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.
⁴ Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA.
⁵ Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. geneyeo@ucsd.edu.
⁶ Stem Cell Program, University of California San Diego, La Jolla, CA, USA. geneyeo@ucsd.edu.
⁷ Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA. geneyeo@ucsd.edu.
⁸ Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA. geneyeo@ucsd.edu.

PMID: 35697782
DOI: 10.1038/s41556-022-00933-9

Abstract

RNA processing plays a central role in accurately transmitting genetic information into functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to observe RNA with high spatial and temporal resolution are critical. Here we review recent advances in RNA imaging and highlight how they will propel the field of RNA biology. We discuss current trends in RNA imaging and their potential to elucidate unanswered questions in RNA biology.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Biology
RNA Processing, Post-Transcriptional*
RNA* / genetics
RNA, Untranslated

Substances

RNA, Untranslated
RNA